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KMID : 0370019940080000049
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Chung-Ang Journal of Pharmacal Sciences
1994 Volume.8 No. 0 p.49 ~ p.56
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Syntheses of Benzothiazole Bivalent Ligand Compounds
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Abstract
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Twelve new bivalent ligands, that contain two benzothiazoles connected by a succinyl or a succinyl bisoligoglycyl chain in a molecule, were prepared and evaluated for antimicrobial activity.
Compound［6］, N, N´ -succinyl bis(6-bromo-2-aminobenzothiazole) showed potent antifungal activity against M. canis and T.mentagrophytes.
Compound［9］,［12］,［13］and ［14］inhibited the growth of M. phlei at the concentration of 62.5㎍/ml.
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